Ph.D., University of Florida, 2000
My research program investigates the interacting biopsychosocial factors that contribute to optimal adaptive outcomes following neurodevelopmental disruption. My interest in brain-behavior relationships is broad, spanning a wide range of research methods, psychological domains, and populations. My research is focused on discovering what happens to the developing brain and to cognitive abilities across the lifespan many years after disorder onset (e.g., brain tumor, congenital heart disease). My team and I investigate white matter pathways using diffusion tensor imaging (DTI) and brain region activations using functional MRI (fMRI) to examine the neural mechanisms underlying both cognitive and social-emotional abilities of individuals. While I initially employed this comprehensive framework to examine the long-term outcomes of survivors of childhood brain tumors, I have extended components of this work to other neurodevelopmental disorders by investigating predictors of adaptive outcomes, neuroimaging studies of cognition, and psychophysiological and neuroimaging studies of emotion.
In 2013, my team and I successfully completed the 6-year Research Scholar Grant awarded by the American Cancer Society (ACS) for this program of research. One new extension of this research is a project in collaboration with Dr. Tobey McDonald, funded by AFLAC Center and Children’s Health Care of Atlanta (CHOA)’s Pediatric Hematology/Oncology Center of Excellence, that examines single nucleotide polymorphisms relationship with cognitive and neuroimaging outcomes of survivors of cerebellar brain tumors. In 2016, we expanded this research with Drs. Phan and Siegel to also examine how these factors relate to sleep outcomes in survivors (funded by CHOA’s Center for Neurosciences Research).
Many of my students have developed clinical neuropsychological evaluation skills and research projects while contributing to these projects. See the video of our research team http://newsarchive.gsu.edu/2013/08/12/grad-student-probes-the-mysteries-of-the-brain-and-behavior/ (at bottom of webpage); at the GSU / Ga Tech Center for Advanced Brain Imaging, where we conduct our research (http://www.cabiatl.com/CABI/).
In August 2016, my research team joined a large multisite consortium study aimed at developing an outcome severity measure and biomarkers for the study of Rett Syndrome (funded by the Rett Syndrome Research Trust). http://reverserett.org/research/consortia/outcome-measures-and-biomarkers-development/ We are developing a much-needed sensitive outcome severity scale that will measure change over time in future clinical trial research with this population.
Over the past year, Dr. Chris Conway and I are completing and extending our pilot project conducted at the CABI, which examined the neural correlates of sequential learning, to a study examining the role of sequential learning in contributing to language and cognitive outcomes in individuals with Autism Spectrum Disorders (funded by the Center for Research on the Challenges of Acquiring Language & Literacy http://researchlanglit.gsu.edu/).
Finally, I am collaborating with Drs. Kathleen O’Toole and Donna Murdaugh at the Children’s Health Care of Atlanta on a study of the efficacy of a time-limited cognitive remediation program. The goal of the intervention is to promote the independence of the children and adolescence in everyday functioning, in order to solidify the foundational skills necessary for eventual transitions to adult healthcare.
All of these collaborations build upon my interests in optimizing outcomes of individuals with neurodevelopmental conditions across the lifespan.
Recent Representative Peer Reviewed Publications
Student mentee co-authors’ names are italicized.
Clark, S., Mittal, V.A., Bernard, JA, Ahmadi, A, King, TZ, & Turner, JA (in press). Stronger default mode network connectivity is associated with poorer clinical insight in youth at ultra high-risk for psychosis. Schizophrenia Research. http://dx.doi.org/10.1016/j.schres.2017.06.043
Ailion, A.S., Hortman, K., King T.Z. (in press). Childhood brain tumors: A systematic review of the structural neuroimaging literature. Neuropsychology Review. DOI: 10.1007/s11065-017-9352-6
Hecht, E.E., Robins, D.L., Gautam, P., & King, T.Z. (2017). Intranasal oxytocin reduces social perception in women: Neural activation and individual variation. Neuroimage, 147, 314-329. doi: 10.1016/j.neuroimage.2016.12.046.
Bradstreet, L.E., Hecht, E.E., King, T.Z., Turner, J.L., & Robins, D.L (2017). Associations between autism traits and fractional anisotropy values in white matter tracts in a nonclinical sample of young adults. Experimental Brain Research, 235 (1), 259-267. doi:10.1007/s00221-016-4791-5
King, T.Z., Smith, K., Burns, T., Sun, B., Shin, J., Jones, R., Drossner, D., Mahle, W. (2017). FMRI investigation of working memory in emerging adults with surgically treated congenital heart disease. Applied Neuropsychology: Child, 6(1), 7-21. http://www.tandfonline.com/doi/abs/10.1080/21622965.2015.1065185
Taiwo, Z., Na, S., & King, T.Z. (2017). The Neurological Predictor Scale: A predictive tool for neurocognitive late effects in survivors of childhood brain tumors. Pediatric Blood and Cancer, 64(1), 172-179. DOI: 10.1002/pbc.26203
Fox, M. & King, TZ. (2016). Pituitary disorders as a predictor of apathy and executive dysfunction in adult survivors of childhood brain tumors. Pediatric Blood and Cancer, 63(11), 2019-2025. DOI: 10.1002/pbc.26144.
Fani, N., King, T.Z., Shin, J., Srivastava, A., Brewster, R.C., Stevens, J.S., Jovanovic, T., Bradley, B., Ressler, K.J. (2016). Structural and functional connectivity and Posttraumatic Stress Disorder: Associations with FKBP5. Depression and Anxiety, 33(4), 300-307.
Chen, H., Wang,L., King, T.Z., & Mao, H. (2016). Increased frontal functional networks in adult survivors of childhood brain tumors. Neuroimage: Clinical, 11, 339-346. http://dx.doi.org/10.1016/j.nicl.2016.02.010
Ailion, A.S., King, T.Z., Wang, L., Fox, M., Mao, H., Morris, R.M., Crosson, B. (2016). Cerebellar Atrophy in Adult Survivors of Childhood Cerebellar Tumor. Journal of the International Neuropsychological Society, 23, 1-11. doi:10.1017/S1355617716000138
King T.Z., Na, S., & Mao, H. (2015). Neural underpinnings of working memory in adult survivors of childhood brain tumors. Journal of the International Neuropsychological Society, 21(7), 494-505. http://dx.doi.org/10.1017/S135561771500051X
King, T.Z., Wang, L., Mao, H. (2015). White Matter Integrity Disruption in Normal Appearing White Matter: Correlates with long-term intellectual outcomes of childhood brain tumor survivors. PLoS One, 10(7): e0131744. journals.plos.org//plosone/article?id=10.1371/journal.pone.0131744
Brewster, R., King, T.Z., Burns, T., Drossner, D., & Mahle, W.T. (2015). White matter integrity dissociates auditory attention span and verbal memory in emerging adults with congenital heart disease. Journal of the International Neuropsychological Society, 21, 22-33.
Jayakar, R., King, T.Z., Morris, R., & Na, S. (2015). Hippocampal volume and auditory attention on a verbal memory task with adult survivors of pediatric brain tumor. Neuropsychology, 29(2), 303-319.
Fani, N., King, T.Z., Brewster, R., Srivastava, A., Stevens, J.S., Glover, E., Norrholm, S.D., Ressler, K.J., & Jovanic, T. (2015). Fear potentiated startle during extinction is associated with white matter microstructure and functional connectivity. Cortex, 64, 249-259.
Fani, N., King, T.Z., Reiser, E., Binder, E., Jovanovic, T., Bradley, R., & Ressler, K. (2014). FKBP5 Genotype and Structural Integrity of the Posterior Cingulum. Neuropsychopharmacology, 39(5):1206-13.
Micklewright, J.L., King, T.Z., O’Toole, K., Henrich, C., & Floyd, F.J. (2012). Parental distress, parenting practices, and child adaptive outcomes following traumatic brain injury. Journal of the International Neuropsychology Society, 18, 1-8.